Home Modern Medicine Fewer calories may increase lifespan, but how?

Fewer calories may increase lifespan, but how?

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Groundbreaking research elucidates the epigenetic mechanism that may be responsible for why eating fewer calories increases longevity.

As early as 1935, scientists showed that limiting the intake of calories can drastically increase the lifespan of mammals.

New research brings us closer to understanding why that may be. Researchers from the Lewis Katz School of Medicine (LKSOM) at Temple University in Philadelphia, PA, have uncovered a mechanism that might explain why calorie restriction has such a beneficial effect on longevity.

The mechanism has to do with epigenetics and bears the name of “methylation drift.”

Scientists led by Dr. Jean-Pierre Issa, director of the Fels Institute for Cancer Research at LKSOM, explain what that means and how they have reached their conclusion in a paper published in the journal Nature Communications.

The study also suggests that the epigenetic mechanism may determine why some mammals live longer than others.